{"id":440,"date":"2006-09-08T01:13:15","date_gmt":"2006-09-07T22:13:15","guid":{"rendered":"http:\/\/zairis.eu\/?post_type=avada_portfolio&#038;p=440"},"modified":"2017-04-04T01:16:47","modified_gmt":"2017-04-03T22:16:47","slug":"the-impact-of-hs-c-reactive-protein-and-other-inflammatory-biomarkers-on-long-term-cardiovascular-mortality-in-patients-with-acute-coronary-syndromes","status":"publish","type":"avada_portfolio","link":"https:\/\/zairis.eu\/el\/portfolio-items\/the-impact-of-hs-c-reactive-protein-and-other-inflammatory-biomarkers-on-long-term-cardiovascular-mortality-in-patients-with-acute-coronary-syndromes\/","title":{"rendered":"The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes"},"content":{"rendered":"<p>We evaluated whether high circulating levels of serum amyloid A (SAA), fibrinogen, interleukin-6 (IL-6) or leukocytes count (LC), can provide any additional predictive value over that provided by hs C-reactive protein (hs-CRP) for the incidence of 5-year cardiovascular mortality, in 458 and 476 consecutive patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation acute coronary syndromes (NSTE-ACS), respectively. By 5 years the incidence of cardiovascular mortalitywas 37.3% and 35.5% in patients with STEMI and NSTE-ACS, respectively. Each of the study inflammatory biomarkers conferred independent to clinical risk predictors (and to cardiac troponin I) long-term prognostic information (all p &lt; 0.05), but only LC provided additional predictive value over that provided by hs-CRP, in either cohort (p &lt; 0.05). By multivariate Cox regression analysis, hs-CRP (p &lt; 0.001 for both cohorts) and LC (p = 0.009 and p &lt; 0.001 for STEMI and NSTE-ACS, respectively) were the only inflammatory biomarkers independently associated with the incidence of 5-year cardiovascular mortality. According to the present results high circulating levels of LC but not of SAA, fibrinogen or IL-6 can provide additional long-term predictive value over that provided by hs-CRP in patients with acute coronary syndromes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We evaluated whether high circulating levels of serum amyloid A (SAA), fibrinogen, interleukin-6 (IL-6) or leukocytes count (LC), can provide any additional predictive value over that provided by hs C-reactive protein (hs-CRP) for the incidence of 5-year cardiovascular mortality, in 458 and 476 consecutive patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation acute  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":432,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[],"portfolio_skills":[],"portfolio_tags":[],"class_list":["post-440","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/comments?post=440"}],"version-history":[{"count":1,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/440\/revisions"}],"predecessor-version":[{"id":442,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/440\/revisions\/442"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media\/432"}],"wp:attachment":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media?parent=440"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_category?post=440"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_skills?post=440"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_tags?post=440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}