{"id":471,"date":"2007-08-21T01:27:48","date_gmt":"2007-08-20T22:27:48","guid":{"rendered":"http:\/\/zairis.eu\/?post_type=avada_portfolio&#038;p=471"},"modified":"2017-04-06T01:40:35","modified_gmt":"2017-04-05T22:40:35","slug":"the-impact-of-aspirin-resistance-on-the-long-term-cardiovascular-mortality-in-patients-with-non-st-segment-elevation-acute-coronary-syndromes","status":"publish","type":"avada_portfolio","link":"https:\/\/zairis.eu\/el\/portfolio-items\/the-impact-of-aspirin-resistance-on-the-long-term-cardiovascular-mortality-in-patients-with-non-st-segment-elevation-acute-coronary-syndromes\/","title":{"rendered":"The Impact of Aspirin Resistance on the Long-term Cardiovascular Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndromes"},"content":{"rendered":"<p><strong>Background:<\/strong> Aspirin resistance has been associated with an adverse long-term outcome in patients with atherosclerotic coronary artery disease, but more studies are needed.<\/p>\n<p><strong>Hypothesis:<\/strong> The aim of this study was to investigate the impact of aspirin resistance, assessed by the Platelet Function Analyzer-100 (PFA-100) (Dade Behring Inc., Deerfield, Ill., USA) on the long-term prognosis in patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS).<\/p>\n<p><strong>Methods:<\/strong> A total of 496 consecutive patients were studied. The 1-y incidence of cardiovascular death was the prespecified study endpoint. The patients were divided, according to the values of PFA-100 collagen epinephrine closure time (CEPI-CT) upon presentation, into aspirin sensitives (those with a PFA-100 CEPI-CT &gt;193 sec) and aspirin resistants (those with a PFA-100 CEPI-CT \u2264193 sec).<\/p>\n<p><strong>Results:<\/strong> Aspirin resistants were younger (p-value = 0.04), and less frequently hypertensives (p-value = 0.05) or diabetics (p-value = 0.04) than aspirin sensitives. By 1 y, the incidence of cardiovascular deaths in the entire cohort was 12.9% (64\/496), and aspirin resistants were at significantly higher risk of cardiovascular death (23.1% versus 9.6%; hazard ratio [HR] = 2.6; 95% confidence interval [CI] = 1.6\u20134.3; p-value &lt;0.001), than aspirin sensitives. By multivariate Cox regression analysis, aspirin resistance (a PFA-100 CEPI-CT \u2264193 sec) was among the most potent predictors of the 1-y incidence of cardiovascular death (HR = 2.8; 95% CI = 1.7\u20134.6; p-value &lt;0.001).<\/p>\n<p><strong>Conclusion:<\/strong> According to the present data, aspirin resistance, assessed by the PFA-100, is an independent predictor of long-term cardiovascular mortality in patients with NSTE-ACS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background: Aspirin resistance has been associated with an adverse long-term outcome in patients with atherosclerotic coronary artery disease, but more studies are needed. Hypothesis: The aim of this study was to investigate the impact of aspirin resistance, assessed by the Platelet Function Analyzer-100 (PFA-100) (Dade Behring Inc., Deerfield, Ill., USA) on the long-term prognosis in  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":474,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[],"portfolio_skills":[],"portfolio_tags":[],"class_list":["post-471","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/comments?post=471"}],"version-history":[{"count":1,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/471\/revisions"}],"predecessor-version":[{"id":473,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/471\/revisions\/473"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media\/474"}],"wp:attachment":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media?parent=471"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_category?post=471"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_skills?post=471"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_tags?post=471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}