{"id":479,"date":"2006-11-14T01:49:23","date_gmt":"2006-11-13T23:49:23","guid":{"rendered":"http:\/\/zairis.eu\/?post_type=avada_portfolio&#038;p=479"},"modified":"2017-04-06T01:55:24","modified_gmt":"2017-04-05T22:55:24","slug":"the-significance-of-circulating-levels-of-both-cardiac-troponin-i-and-high-sensitivity-c-reactive-protein-for-the-prediction-of-intravenous-thrombolysis-outcome-in-patients-with-st-segment-elevation-m","status":"publish","type":"avada_portfolio","link":"https:\/\/zairis.eu\/el\/portfolio-items\/the-significance-of-circulating-levels-of-both-cardiac-troponin-i-and-high-sensitivity-c-reactive-protein-for-the-prediction-of-intravenous-thrombolysis-outcome-in-patients-with-st-segment-elevation-m\/","title":{"rendered":"The significance of circulating levels of both cardiac troponin I and high-sensitivity C reactive protein for the prediction of intravenous thrombolysis outcome in patients with ST-segment elevation myocardial infarction"},"content":{"rendered":"<p><strong>Objectives:<\/strong> To evaluate, using continuous 12-lead ECG ST-segment monitoring, the role of circulating levels of both cardiac troponin I (cTnI) and high-sensitivity C reactive protein (hs-CRP), on presentation, in the prediction of intravenous thrombolysis outcome in patients with ST-segment elevation myocardial infarction (STEMI).<\/p>\n<p><strong>Design and setting:<\/strong> Prospective observational study in a tertiary referral centre.<\/p>\n<p><strong>Patients:<\/strong> 786 consecutive patients with STEMI, who received intravenous thrombolysis in the first 6 h from index pain.<\/p>\n<p><strong>Main outcome measures:<\/strong> The incidence of failed thrombolysis and of cardiac death by 30 days. Failed thrombolysis was defined as the absence of abrupt and sustained &gt;50% ST-segment recovery in the first 90 min after the initiation of intravenous thrombolysis.<\/p>\n<p><strong>Results:<\/strong> The incidence of failed thrombolysis and 30-day cardiac death was 57.4% and 11.8%, respectively. By multivariate logistic regression analysis according to tertiles of both cTnI (RR, 1.5; 95% CI 1.1 to 1.8, p = 0.004 for highest vs middle third; 2.2, 1.9 to 3.5, p,0.001 for highest vs lowest third; 1.5, 1.2 to 1.8, p = 0.001 for middle vs lowest third) and hs-CRP (RR, 2.0, 95% CI, 1.6 to 2.2; p,0.001 for highest vs middle third; 2.6, 2.1 to 3.5, p,0.001 for highest vs lowest third; 1.3, 1.2 to 1.7, p = 0.02 for middle vs lowest third), were independently associated with failed thrombolysis. Moreover, by multivariate Cox regression analysis according to tertiles of both cTnI (HR 1.2, 95% CI 1.1 to 1.8, p = 0.03 for highest vs middle third; 1.5, 1.2 to 2.2, p = 0.004 for highest vs lowest third; 1.1, 0.6 to 1.4, p = 0.6 for middle vs lowest third) and hs-CRP (HR1.2, 95% CI 1.1 to 1.6, p = 0.04 for highest vs middle third; 1.7, 1.3 to 2.6, p = 0.001 for highest vs lowest third; 1.1, 0.9 to 2.1, p = 0.1 for middle vs lowest third), were independently related with an increased risk of 30-day cardiac death.<\/p>\n<p><strong>Conclusions:<\/strong> High circulating levels of both cTnI and hs-CRP are related with an independent increased risk of intravenous thrombolysis failure and 30-day cardiac death in patients who received intravenous thrombolysis in the first 6 h of STEMI.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives: To evaluate, using continuous 12-lead ECG ST-segment monitoring, the role of circulating levels of both cardiac troponin I (cTnI) and high-sensitivity C reactive protein (hs-CRP), on presentation, in the prediction of intravenous thrombolysis outcome in patients with ST-segment elevation myocardial infarction (STEMI). Design and setting: Prospective observational study in a tertiary referral centre. Patients:  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":482,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"footnotes":""},"portfolio_category":[],"portfolio_skills":[],"portfolio_tags":[],"class_list":["post-479","avada_portfolio","type-avada_portfolio","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio"}],"about":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/types\/avada_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/comments?post=479"}],"version-history":[{"count":1,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/479\/revisions"}],"predecessor-version":[{"id":480,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/avada_portfolio\/479\/revisions\/480"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media\/482"}],"wp:attachment":[{"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/media?parent=479"}],"wp:term":[{"taxonomy":"portfolio_category","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_category?post=479"},{"taxonomy":"portfolio_skills","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_skills?post=479"},{"taxonomy":"portfolio_tags","embeddable":true,"href":"https:\/\/zairis.eu\/el\/wp-json\/wp\/v2\/portfolio_tags?post=479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}